PTGFR and PTGES2

Number of citations of the paper that reports this interaction (PubMedID 8300593)
43

Data Source:
HPRD (in vivo)

		PTGFR	PTGES2
Description		prostaglandin F receptor	prostaglandin E synthase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Extracellular Region Nucleus Mitochondrion Cytosol Integral Component Of Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	Prostaglandin F Receptor Activity	DNA Binding Protein Binding Lyase Activity Heme Binding 12-hydroxyheptadecatrienoic Acid Synthase Activity Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Lipid Metabolic Process Glutathione Metabolic Process Cyclooxygenase Pathway Positive Regulation Of Transcription, DNA-templated Secretion
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases
GWAS		Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Body mass index ( 26426971)
Interacting Genes		12 interacting genes: AGTR1 CTH FPGT GTPBP4 IKBKE NOC2L PHOX2B PTGDS PTGER1 PTGER2 PTGES2 PTPRT	9 interacting genes: ADRB2 C9orf78 CEBPB CFAP141 COL23A1 CRY2 EXOSC10 PTGFR RPL27A
Entrez ID		5737	80142
HPRD ID		08988	07458
Ensembl ID		ENSG00000122420	ENSG00000148334
Uniprot IDs		P43088	A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7
PDB IDs
Enriched GO Terms of Interacting Partners?
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