ADAMTSL3 and RAMAC

		ADAMTSL3	RAMAC
Description		ADAMTS like 3	RNA guanine-7 methyltransferase activating subunit
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm MRNA Cap Binding Complex MRNA Cap Methyltransferase Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding	RNA Binding Protein Binding Enzyme Activator Activity
	Biological Process	Extracellular Matrix Organization	7-methylguanosine MRNA Capping Methylation Recruitment Of MRNA Capping Enzyme To RNA Polymerase II Holoenzyme Complex Regulation Of Catalytic Activity RNA 5'-cap (guanine-N7)-methylation
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Asthma ( 34103634 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Chronic obstructive pulmonary disease ( 30804561 33909500) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 33713608 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hip index ( 34021172) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 26785701 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: ALPK3 BNC1 CYSRT1 EFL1 GLRX3 GOLGA2P10 HDGFL3 IDH3A KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-6 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP5-7 MDFI NOTCH2NLA RAMAC	48 interacting genes: ADAMTSL3 AKAP8L BAG4 BPIFA1 C10orf55 CYSRT1 DAB1 DAZAP2 DMRTB1 FAM168B FOXI1 GOLGA2 HNRNPH1 HNRNPK INCA1 KRT15 KRT31 KRT33B KRTAP1-3 KRTAP8-1 LZTS2 MAGED1 MAPK1IP1L NAF1 OXER1 PEA15 PLSCR1 PLSCR4 POU2AF1 PRR3 PSMA3 RBMX RBMY1F RBPMS RHOXF2 RINT1 RNMT SF3B4 SNRPC TEKT3 TEKT4 TNS2 TRIM23 TRIM27 TRIM42 USP54 VPS37C WWOX
Entrez ID		57188	83640
HPRD ID		12426	12845
Ensembl ID		ENSG00000156218	ENSG00000169612
Uniprot IDs		P82987	Q9BTL3
PDB IDs			5E8J
Enriched GO Terms of Interacting Partners?
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