PNPLA2 and ARFGEF2

Number of citations of the paper that reports this interaction (PubMedID 21789191)
31

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PNPLA2	ARFGEF2
Description		patatin like phospholipase domain containing 2	ADP ribosylation factor guanine nucleotide exchange factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Golgi Membrane Golgi Apparatus Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Lipoprotein Lipase Activity Triglyceride Lipase Activity Acylglycerol O-acyltransferase Activity Retinyl-palmitate Esterase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Diacylglycerol Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body shape index ( 34021172) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Keratoconus ( 31855235) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	11 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A PTGIS SLC9A8
Entrez ID		57104	10564
HPRD ID		11443	09250
Ensembl ID		ENSG00000177666	ENSG00000124198
Uniprot IDs		Q96AD5	Q59FR3 Q86TH5 Q9Y6D5
PDB IDs			3L8N 3SWV
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?