SPIRE1 and PLEKHA5

		SPIRE1	PLEKHA5
Description		spire type actin nucleation factor 1	pleckstrin homology domain containing A5
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton Cell Cortex Cytoplasmic Vesicle Membrane Integral Component Of Mitochondrial Outer Membrane Cleavage Furrow Perinuclear Region Of Cytoplasm	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Actin Cytoskeleton Organization Actin Filament Polymerization Cleavage Furrow Formation Polar Body Extrusion After Meiotic Divisions Actin Nucleation Intracellular Transport Golgi Vesicle Transport Establishment Of Meiotic Spindle Localization Actin Filament Network Formation Formin-nucleated Actin Cable Assembly Positive Regulation Of Mitochondrial Fission Positive Regulation Of Double-strand Break Repair	Biological_process Reproductive System Development
Pathways			Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Red blood cell count ( 32888494)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes		4 interacting genes: BBS4 CEP192 ETS1 PLEKHA5	36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		56907	54477
HPRD ID		11600	09684
Ensembl ID		ENSG00000134278	ENSG00000052126
Uniprot IDs		Q08AE8	A0A024RAY7 Q9HAU0
PDB IDs		2YLE 2YLF 3R7G 3RBW	2DKP
Enriched GO Terms of Interacting Partners?
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