PLEKHA5 and ADK

		PLEKHA5	ADK
Description		pleckstrin homology domain containing A5	adenosine kinase
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	RNA Binding Adenosine Kinase Activity ATP Binding Metal Ion Binding
	Biological Process	Biological_process Reproductive System Development	Purine Ribonucleoside Salvage DATP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Phosphorylation AMP Salvage
Pathways		Synthesis of PIPs at the plasma membrane	Purine salvage
Drugs			Adenosine phosphate 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Adult body size ( 32376654) Cardiac troponin-I levels ( 31014085) Diverticular disease ( 30177863) Drug experimentation measurement ( 30718321) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypospadias ( 25108383) Lymphocyte counts ( 32888494) Permanent tooth development ( 21931568) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 30578418)
Interacting Genes		36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	3 interacting genes: FICD PLEKHA5 SRD5A3
Entrez ID		54477	132
HPRD ID		09684	00039
Ensembl ID		ENSG00000052126	ENSG00000156110
Uniprot IDs		A0A024RAY7 Q9HAU0	A0A140VJE0 A0A5F9ZH72 A0A5F9ZHJ1 P55263
PDB IDs		2DKP	1BX4 2I6A 2I6B 4O1L
Enriched GO Terms of Interacting Partners?
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