PSAP and USP4

Number of citations of the paper that reports this interaction (PubMedID 23022198)
7

Data Source:
BioGRID (two hybrid)

		PSAP	USP4
Description		prosaposin	ubiquitin specific peptidase 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Thiol-dependent Deubiquitinase Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface
Pathways		Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
GWAS		Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		21 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1	50 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Entrez ID		5660	7375
HPRD ID		01460	04598
Ensembl ID		ENSG00000197746	ENSG00000114316
Uniprot IDs		A0A024QZQ2 P07602	A0A024R2W0 A0A024R2X6 A1LPW7 Q08AK7 Q13107
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR	2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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