USP4 and ATP1B3

Number of citations of the paper that reports this interaction (PubMedID 23022198)
7

Data Source:
BioGRID (two hybrid)

		USP4	ATP1B3
Description		ubiquitin specific peptidase 4	ATPase Na+/K+ transporting subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Basolateral Plasma Membrane Apical Plasma Membrane Sperm Flagellum Melanosome Extracellular Exosome
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding	ATPase Activator Activity P-type Sodium:potassium-exchanging Transporter Activity Protein Binding Protein-macromolecule Adaptor Activity ATPase Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Catalytic Activity Protein Stabilization Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 27841878) Red cell distribution width ( 32888494 27863252 28957414) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 26503584) Total hippocampal volume ( 30279459) Waist-hip ratio ( 28552196) White blood cell count ( 32888494)
Interacting Genes		50 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28	15 interacting genes: BAALC BARD1 BRCA1 CTXN3 MYCBP2 NLRP3 OGT PAXIP1 PEA15 SMAGP STOM TMEM98 TRIM14 UPF2 USP4
Entrez ID		7375	483
HPRD ID		04598	03521
Ensembl ID		ENSG00000114316	ENSG00000069849
Uniprot IDs		A0A024R2W0 A0A024R2X6 A1LPW7 Q08AK7 Q13107	P54709
PDB IDs		2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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