KCNQ5 and POU3F2

		KCNQ5	POU3F2
Description		potassium voltage-gated channel subfamily Q member 5	POU class 3 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Clathrin Coat	Chromatin Nucleoplasm Transcription Regulator Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Epidermis Development Negative Regulation Of Gene Expression Astrocyte Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Hypothalamus Cell Differentiation Neurohypophysis Development Myelination In Peripheral Nervous System Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Axonogenesis Cellular Response To Organic Substance
Pathways		Voltage gated Potassium channels	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Enflurane Gabapentin Promethazine Miconazole Ezogabine ICA-105665
Diseases
GWAS		Carotid plaque burden ( 28282560) Cataracts ( 34127677) Frontal pole volume ( 31530798) High myopia ( 31816047) HIV-1 viral setpoint ( 26039976) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Myopia ( 27182965) Optic disc size ( 31809533) Peak expiratory flow ( 30804560) Periodontitis ( 25672891) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 30224653) Refractive error ( 23396134 32231278) Rosacea symptom severity ( 29771307) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Total body bone mineral density ( 30172743) Upper eyelid sagging severity ( 24869959) Western dietary pattern ( 28644415)	Bipolar disorder ( 33263727 24618891 27329760) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Caffeine consumption from coffee or tea ( 33287642) Chronotype ( 30696823) Educational attainment ( 25201988) Erectile dysfunction ( 30583798) General risk tolerance (MTAG) ( 30643258) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval (drug interaction) ( 23459443) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		8 interacting genes: CALM1 CALM2 CALM3 DISC1 KCNQ3 MTDH POU3F2 SRC	15 interacting genes: COASY EP300 GTF2B KCNQ5 LGALS13 NFYA NFYB NFYC PAX3 POU3F4 PQBP1 SMIM8 SOX10 SOX11 TBP
Entrez ID		56479	5454
HPRD ID		16241	02734
Ensembl ID		ENSG00000185760	ENSG00000184486
Uniprot IDs		Q9NR82	P20265
PDB IDs		6B8Q
Enriched GO Terms of Interacting Partners?
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