POU3F2 and KCNQ5

		POU3F2	KCNQ5
Description		POU class 3 homeobox 2	potassium voltage-gated channel subfamily Q member 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Clathrin Coat
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Epidermis Development Negative Regulation Of Gene Expression Astrocyte Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Hypothalamus Cell Differentiation Neurohypophysis Development Myelination In Peripheral Nervous System Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Axonogenesis Cellular Response To Organic Substance	Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Voltage gated Potassium channels
Drugs			Enflurane Gabapentin Promethazine Miconazole Ezogabine ICA-105665
Diseases
GWAS		Bipolar disorder ( 33263727 24618891 27329760) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Caffeine consumption from coffee or tea ( 33287642) Chronotype ( 30696823) Educational attainment ( 25201988) Erectile dysfunction ( 30583798) General risk tolerance (MTAG) ( 30643258) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval (drug interaction) ( 23459443) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Carotid plaque burden ( 28282560) Cataracts ( 34127677) Frontal pole volume ( 31530798) High myopia ( 31816047) HIV-1 viral setpoint ( 26039976) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Myopia ( 27182965) Optic disc size ( 31809533) Peak expiratory flow ( 30804560) Periodontitis ( 25672891) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 30224653) Refractive error ( 23396134 32231278) Rosacea symptom severity ( 29771307) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Total body bone mineral density ( 30172743) Upper eyelid sagging severity ( 24869959) Western dietary pattern ( 28644415)
Interacting Genes		15 interacting genes: COASY EP300 GTF2B KCNQ5 LGALS13 NFYA NFYB NFYC PAX3 POU3F4 PQBP1 SMIM8 SOX10 SOX11 TBP	8 interacting genes: CALM1 CALM2 CALM3 DISC1 KCNQ3 MTDH POU3F2 SRC
Entrez ID		5454	56479
HPRD ID		02734	16241
Ensembl ID		ENSG00000184486	ENSG00000185760
Uniprot IDs		P20265	Q9NR82
PDB IDs			6B8Q
Enriched GO Terms of Interacting Partners?
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