POU3F2 and PQBP1

Number of citations of the paper that reports this interaction (PubMedID 10332029)
33

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		POU3F2	PQBP1
Description		POU class 3 homeobox 2	polyglutamine binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Nuclear Body Nuclear Speck Neuronal Ribonucleoprotein Granule
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Epidermis Development Negative Regulation Of Gene Expression Astrocyte Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Hypothalamus Cell Differentiation Neurohypophysis Development Myelination In Peripheral Nervous System Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Axonogenesis Cellular Response To Organic Substance	Alternative MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Regulation Of Transcription, DNA-templated Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 33263727 24618891 27329760) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Caffeine consumption from coffee or tea ( 33287642) Chronotype ( 30696823) Educational attainment ( 25201988) Erectile dysfunction ( 30583798) General risk tolerance (MTAG) ( 30643258) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval (drug interaction) ( 23459443) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		15 interacting genes: COASY EP300 GTF2B KCNQ5 LGALS13 NFYA NFYB NFYC PAX3 POU3F4 PQBP1 SMIM8 SOX10 SOX11 TBP	24 interacting genes: APBB1 APP AQR ATXN1 CLTB EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77
Entrez ID		5454	10084
HPRD ID		02734	02354
Ensembl ID		ENSG00000184486	ENSG00000102103
Uniprot IDs		P20265	A0A0S2Z4V5 O60828
PDB IDs			4BWQ 4BWS 4CDO
Enriched GO Terms of Interacting Partners?
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