PPP3CC and PPP3R1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		PPP3CC	PPP3R1
Description		protein phosphatase 3 catalytic subunit gamma	protein phosphatase 3 regulatory subunit B, alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Calcineurin Complex Presynapse Glutamatergic Synapse	Nucleoplasm Cytosol Calcineurin Complex Sarcolemma Schaffer Collateral - CA1 Synapse Parallel Fiber To Purkinje Cell Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Calmodulin Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Cyclosporin A Binding Phosphatase Binding Protein Domain Specific Binding
	Biological Process	Protein Dephosphorylation Brain Development Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Synaptic Vesicle Endocytosis	Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Protein Dephosphorylation Protein Import Into Nucleus Heart Development Myelination In Peripheral Nervous System Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Lung Epithelial Cell Differentiation Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events	Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs			Myristic acid Voclosporin
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)	General cognitive ability ( 29844566) Height ( 25282103) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)
Interacting Genes		19 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B ENTPD4 GFRA2 HAX1 ITPKC LEPROTL1 PPP3R1 SDC2 SLC18A1 SORBS3 SPATA33 TGFBR1 THAP7 UNC119	11 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA PPP3CC WDPCP
Entrez ID		5533	5534
HPRD ID		00236	03195
Ensembl ID		ENSG00000120910	ENSG00000221823
Uniprot IDs		P48454	P63098
PDB IDs			1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?