PPP3R1

Description		protein phosphatase 3 regulatory subunit B, alpha
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Calcineurin Complex Sarcolemma Schaffer Collateral - CA1 Synapse Parallel Fiber To Purkinje Cell Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Cyclosporin A Binding Phosphatase Binding Protein Domain Specific Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Protein Dephosphorylation Protein Import Into Nucleus Heart Development Myelination In Peripheral Nervous System Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Lung Epithelial Cell Differentiation Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Myristic acid Voclosporin
Diseases
GWAS		General cognitive ability ( 29844566) Height ( 25282103) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)
Interacting Genes		11 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA PPP3CC WDPCP
Entrez ID		5534
HPRD ID		03195
Ensembl ID		ENSG00000221823
Uniprot IDs		P63098
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
Tagcloud ?