SBNO1 and ANAPC5

		SBNO1	ANAPC5
Description		strawberry notch homolog 1	anaphase promoting complex subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Nucleus Nucleoplasm Anaphase-promoting Complex Spindle Cytosol
	Molecular Function	Molecular_function Chromatin DNA Binding Histone Binding	Protein Phosphatase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Biological_process	Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878 27618447) Educational attainment ( 25201988) HDL cholesterol ( 24097068 30275531 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Head circumference (infant) ( 22504419) Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Knee osteoarthritis ( 30374069) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: ANAPC5 ARL6IP4 DIABLO GSK3A TRIAP1 ZCCHC8	12 interacting genes: BACH1 CREBBP FBXO5 FZR1 MAPK6 PABPC1 SBNO1 SMURF1 SMURF2 TGFBR1 UBE2S ZBTB16
Entrez ID		55206	51433
HPRD ID		11533	10453
Ensembl ID		ENSG00000139697	ENSG00000089053
Uniprot IDs		A3KN83	B4DFK4 F5H0F9 Q9UJX4
PDB IDs			4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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