ANAPC5 and SBNO1

		ANAPC5	SBNO1
Description		anaphase promoting complex subunit 5	strawberry notch homolog 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Spindle Cytosol	Cellular_component Nucleus
	Molecular Function	Protein Phosphatase Binding	Molecular_function Chromatin DNA Binding Histone Binding
	Biological Process	Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination	Regulation Of Transcription, DNA-templated Biological_process
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878 27618447) Educational attainment ( 25201988) HDL cholesterol ( 24097068 30275531 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Head circumference (infant) ( 22504419) Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Knee osteoarthritis ( 30374069) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: BACH1 CREBBP FBXO5 FZR1 MAPK6 PABPC1 SBNO1 SMURF1 SMURF2 TGFBR1 UBE2S ZBTB16	6 interacting genes: ANAPC5 ARL6IP4 DIABLO GSK3A TRIAP1 ZCCHC8
Entrez ID		51433	55206
HPRD ID		10453	11533
Ensembl ID		ENSG00000089053	ENSG00000139697
Uniprot IDs		B4DFK4 F5H0F9 Q9UJX4	A3KN83
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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