PPP1R8 and SF3B1

Number of citations of the paper that reports this interaction (PubMedID 12105215)
28

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PPP1R8	SF3B1
Description		protein phosphatase 1 regulatory subunit 8	splicing factor 3b subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding RNA Binding MRNA Binding Endonuclease Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding
	Biological Process	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing Negative Regulation Of Protein Dephosphorylation Negative Regulation Of Catalytic Activity RNA Phosphodiester Bond Hydrolysis	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing
Pathways			B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs			H3B-8800
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		27 interacting genes: APP APPBP2 CDC5L CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77	104 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DUX4 DYRK1A ERG GTF3C3 HSPD1 IL7R MELK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC NOP58 NUDT21 PHF5A PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 STRADB SUMO2 TCERG1 TOP1 U2AF2 WBP4
Entrez ID		5511	23451
HPRD ID		04028	09281
Ensembl ID		ENSG00000117751	ENSG00000115524
Uniprot IDs		Q12972 Q6ICT4	B4DGZ4 O75533
PDB IDs		3V4Y	2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI
Enriched GO Terms of Interacting Partners?
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