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SF3B1 and HSPD1
SF3B1
HSPD1
Description
splicing factor 3b subunit 1
heat shock protein family D (Hsp60) member 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
U2 SnRNP
U12-type Spliceosomal Complex
Nuclear Speck
U11/U12 SnRNP
U2-type Prespliceosome
U2-type Precatalytic Spliceosome
Catalytic Step 2 Spliceosome
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Matrix
Early Endosome
Peroxisomal Matrix
Rough Endoplasmic Reticulum
Cytosol
Plasma Membrane
Clathrin-coated Pit
Cell Surface
Membrane
Mitochondrial Crista
Coated Vesicle
Secretory Granule
Golgi Cisterna
Protein-containing Complex
Zymogen Granule
Membrane Raft
Lipopolysaccharide Receptor Complex
Extracellular Exosome
Sperm Midpiece
Molecular Function
RNA Binding
MRNA Binding
Protein Binding
Splicing Factor Binding
Lipopolysaccharide Binding
P53 Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
RNA Binding
Double-stranded RNA Binding
Protein Binding
ATP Binding
High-density Lipoprotein Particle Binding
Isomerase Activity
ATP Hydrolysis Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Apolipoprotein Binding
Apolipoprotein A-I Binding
Unfolded Protein Binding
Chaperone Binding
Modification-dependent Protein Binding
Biological Process
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
RNA Splicing
Response To Hypoxia
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Response To Ischemia
Protein Folding
'de Novo' Protein Folding
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Unfolded Protein
Apoptotic Mitochondrial Changes
Response To Cold
Response To Xenobiotic Stimulus
Response To Activity
Response To Lipopolysaccharide
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To ATP
Mitochondrial Unfolded Protein Response
Cellular Response To Heat
Protein Refolding
B Cell Proliferation
T Cell Activation
B Cell Activation
Response To Cocaine
Response To Hydrogen Peroxide
Positive Regulation Of Macrophage Activation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Response To Estrogen
Adhesion Of Symbiont To Host
Protein Import Into Mitochondrial Intermembrane Space
Isotype Switching To IgG Isotypes
Positive Regulation Of Inflammatory Response
Protein Stabilization
Positive Regulation Of T Cell Activation
Chaperone-mediated Protein Complex Assembly
Response To Glucocorticoid
Protein Maturation
Biological Process Involved In Interaction With Symbiont
Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Cellular Response To Interleukin-7
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways
B-WICH complex positively regulates rRNA expression
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Mitochondrial protein import
Mitochondrial protein import
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
H3B-8800
Copper
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Major depressive disorder (
27479909
)
Morning person (
30696823
)
Schizophrenia (
25056061
29483656
30285260
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Waist circumference adjusted for body mass index (
34021172
)
Autism spectrum disorder or schizophrenia (
28540026
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Schizophrenia (
25056061
29483656
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
104 interacting genes:
APBB1
C11orf58
CALM1
CLK1
CSNK2A1
DUX4
DYRK1A
ERG
GTF3C3
HSPD1
IL7R
MELK
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MYC
NOP58
NUDT21
PHF5A
PLRG1
PPP1R8
PRPF40A
SF1
SF3B3
SF3B6
SMAD1
SMAD5
SMAD9
SNIP1
STRADB
SUMO2
TCERG1
TOP1
U2AF2
WBP4
61 interacting genes:
ALDH2
APP
BAK1
BRCA1
CA2
CASP3
CASP6
CASP9
CEP70
CLEC7A
CLU
CYSRT1
DHFR
DUX4
ERBB2
ERG
FAM107A
FHIT
GLI2
H2BC21
HSPE1
ITGA3
ITGB1
KCTD10
KRT31
KRT34
KRT40
KRTAP10-3
KRTAP10-8
KRTAP5-9
LINC01554
LRRK2
LZTS2
MAPK6
MCPH1
MGAT3
MOB4
NOS1AP
NOTCH2NLA
NR3C1
OGT
PLCG2
PLG
PPP2R1A
PPP2R1B
PRKACA
PRNP
PTEN
PTPN11
RASA1
RGS20
SAMD3
SF3B1
SUMO2
SUMO4
SUPT6H
TLR1
TMCC2
TRIM63
UBASH3A
YWHAG
Entrez ID
23451
3329
HPRD ID
09281
00318
Ensembl ID
ENSG00000115524
ENSG00000144381
Uniprot IDs
B4DGZ4
O75533
A0A024R3X4
P10809
PDB IDs
2F9D
2F9J
2FHO
2PEH
3LQV
4OZ1
5IFE
5O9Z
5Z56
5Z57
5Z58
5ZYA
6AH0
6EN4
6FF4
6FF7
6N3E
6QX9
6Y50
6Y53
6Y5Q
7ABG
7ABH
7ABI
4PJ1
6HT7
6MRC
6MRD
7AZP
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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