SF3B1 and MIR21

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		SF3B1	MIR21
Description		splicing factor 3b subunit 1	microRNA 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Extracellular Space Cytoplasm Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing	Blood Vessel Development Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Negative Regulation Of NF-kappaB Transcription Factor Activity Activation Of Protein Kinase B Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-21 Production Collagen Metabolic Process Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Phenotypic Switching Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Inflammatory Response Negative Regulation Of Stress Fiber Assembly Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of Cartilage Development Endothelial Tube Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Gamma Radiation Cellular Response To Virus Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cellular Response To Hypoxia Negative Regulation Of Arginine Catabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Superoxide Dismutase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Resveratrol Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Replicative Senescence Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Tube Morphogenesis Retinal Cell Apoptotic Process Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		H3B-8800
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Monocyte count ( 29403010)
Interacting Genes		104 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DUX4 DYRK1A ERG GTF3C3 HSPD1 IL7R MELK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC NOP58 NUDT21 PHF5A PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 STRADB SUMO2 TCERG1 TOP1 U2AF2 WBP4	95 interacting genes: AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CELF2 CPSF1 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUFIP2 PATL1 PDCD11 PGAM5 PTBP1 PTBP3 PTCD3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM17 RBM4 RBM4B RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF106
Entrez ID		23451	406991
HPRD ID		09281
Ensembl ID		ENSG00000115524	ENSG00000284190
Uniprot IDs		B4DGZ4 O75533
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI
Enriched GO Terms of Interacting Partners?
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