PPP1R1A and PPP1R15A

Number of citations of the paper that reports this interaction (PubMedID 11564868)
116

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPP1R1A	PPP1R15A
Description		protein phosphatase 1 regulatory inhibitor subunit 1A	protein phosphatase 1 regulatory subunit 15A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Glycogen Metabolic Process Intracellular Signal Transduction Negative Regulation Of Catalytic Activity	Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Dephosphorylation
Pathways			Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Hip circumference ( 28552196) Waist circumference ( 28552196)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		2 interacting genes: PPP1R15A RNF41	16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		5502	23645
HPRD ID		17893	06572
Ensembl ID		ENSG00000135447	ENSG00000087074
Uniprot IDs		Q13522	O75807
PDB IDs			4XPN
Enriched GO Terms of Interacting Partners?
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