PPP1R15A and TSN

Number of citations of the paper that reports this interaction (PubMedID 10434033)
4

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		PPP1R15A	TSN
Description		protein phosphatase 1 regulatory subunit 15A	translin
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Protein Phosphatase Activator Activity	DNA Binding Single-stranded DNA Binding RNA Binding Endonuclease Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Dephosphorylation	DNA Recombination RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency	Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration ( 29346644) Erectile dysfunction and prostate cancer treatment ( 20932654) Food antigen IgG levels ( 24962563) Hepcidin/ferritin ratio ( 27846281) Major depressive disorder x sex interaction ( 34099189) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Smoking status (ever vs never smokers) ( 30643258) Waist circumference ( 34074324)
Interacting Genes		16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	16 interacting genes: CFC1 DVL3 FXR1 GIT2 GORASP2 LNX1 MORF4L2 NTAQ1 PICK1 PPP1R15A SDCBP SIN3A TSNAX UBE2I UBE2K ZBTB18
Entrez ID		23645	7247
HPRD ID		06572	08993
Ensembl ID		ENSG00000087074	ENSG00000211460
Uniprot IDs		O75807	B3KRM8 Q15631
PDB IDs		4XPN	1J1J 3PJA 3QB5 4WYV
Enriched GO Terms of Interacting Partners?
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