GATAD2A and MBD2

Number of citations of the paper that reports this interaction (PubMedID 12183469)
36

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GATAD2A	MBD2
Description		GATA zinc finger domain containing 2A	methyl-CpG binding domain protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm NuRD Complex Nuclear Speck	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding	Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling DNA Methylation-dependent Heterochromatin Assembly Heart Development Aging Response To Mechanical Stimulus Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Cellular Protein-containing Complex Assembly Positive Regulation Of Chromatin Binding Regulation Of Cell Population Proliferation Maternal Behavior Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Embryonic Organ Development Cellular Response To Organic Cyclic Compound
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cirrhosis (alcohol related) ( 32853455) Height ( 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Serum metabolite levels ( 33031748) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)
Interacting Genes		22 interacting genes: ARRDC2 BABAM1 BST2 CBFA2T3 CREBBP H2AC20 H2BC21 H3C1 H4C1 ISYNA1 ITGB3BP KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 MBD3L1 PAK4 RASA2 SPOP TMEM161A	21 interacting genes: BEND7 C1QBP CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 PRMT1 PURB RALYL RBBP4 SIN3A SMN2 TBP
Entrez ID		54815	8932
HPRD ID		11741	04647
Ensembl ID		ENSG00000167491	ENSG00000134046
Uniprot IDs		A0A024R7K7 A0A024R7M6 Q86YP4	A0A024R2B8 Q9UBB5
PDB IDs		2L2L	2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ 7AO8 7AO9 7AOA
Enriched GO Terms of Interacting Partners?
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