MBD2 and RBBP4

Number of citations of the paper that reports this interaction (PubMedID 10471499)
233

Data Source:
HPRD (in vivo, in vitro)

		MBD2	RBBP4
Description		methyl-CpG binding domain protein 2	RB binding protein 4, chromatin remodeling factor
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Sin3 Complex NuRD Complex NURF Complex Protein-containing Complex CAF-1 Complex ESC/E(Z) Complex
	Molecular Function	Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding ATP-dependent Activity, Acting On DNA Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling DNA Methylation-dependent Heterochromatin Assembly Heart Development Aging Response To Mechanical Stimulus Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Cellular Protein-containing Complex Assembly Positive Regulation Of Chromatin Binding Regulation Of Cell Population Proliferation Maternal Behavior Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Embryonic Organ Development Cellular Response To Organic Cyclic Compound	DNA Replication DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Cell Cycle Negative Regulation Of Cell Population Proliferation Chromatin Assembly
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)
Interacting Genes		21 interacting genes: BEND7 C1QBP CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 PRMT1 PURB RALYL RBBP4 SIN3A SMN2 TBP	63 interacting genes: AEBP2 ANXA7 ARMC12 BCL11A BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP CYTOR DHX30 ERCC6 ESR1 FOXK2 H1-1 H2AC20 H3-4 H3C1 H3C14 H4-16 H4C14 HDAC1 HDAC2 HDAC3 HDAC4 HMOX2 ING1 KPNA3 KPNA5 LIN9 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 MYBL2 NR2E3 OGT PRDM16 RB1 RBBP7 RBP1 RPN1 RPN2 RYBP SALL4 SAP30 SIN3A SMN1 SP1 SP3 SPEN STAT5B SUMO2 SUV39H1 SUZ12 TK1 TSSK3 XRCC6
Entrez ID		8932	5928
HPRD ID		04647	04232
Ensembl ID		ENSG00000134046	ENSG00000162521
Uniprot IDs		A0A024R2B8 Q9UBB5	Q09028
PDB IDs		2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ 7AO8 7AO9 7AOA	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY 5VTB 5WAI 5WAK 5XWR 5XXQ 5Y1U 6BW3 6BW4 6C23 6C24 6G16 6NQ3 6WKR 6ZRC 6ZRD 7AOA 7KSO 7KSR 7KTP
Enriched GO Terms of Interacting Partners?
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