MBD2 and PURB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MBD2	PURB
Description		methyl-CpG binding domain protein 2	purine rich element binding protein B
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex	Nucleus Nucleoplasm
	Molecular Function	Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Purine-rich Negative Regulatory Element Binding SMAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling DNA Methylation-dependent Heterochromatin Assembly Heart Development Aging Response To Mechanical Stimulus Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Cellular Protein-containing Complex Assembly Positive Regulation Of Chromatin Binding Regulation Of Cell Population Proliferation Maternal Behavior Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Embryonic Organ Development Cellular Response To Organic Cyclic Compound	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Cell Differentiation Regulation Of Myeloid Cell Differentiation
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)	Platelet count ( 27863252)
Interacting Genes		21 interacting genes: BEND7 C1QBP CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 PRMT1 PURB RALYL RBBP4 SIN3A SMN2 TBP	22 interacting genes: AP1M1 CSNK2A1 IL7R LNX1 MBD2 MIR128-1 MIR128-2 MIR25 MIR29C MIR31 MIR34B MIR363 MIR7-1 MIR7-3 MIR9-2 MIRLET7A3 MIRLET7G MIRLET7I NABP1 PCDHB14 PURA ZNF497
Entrez ID		8932	5814
HPRD ID		04647	12325
Ensembl ID		ENSG00000134046	ENSG00000146676
Uniprot IDs		A0A024R2B8 Q9UBB5	Q96QR8
PDB IDs		2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ 7AO8 7AO9 7AOA
Enriched GO Terms of Interacting Partners?
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