AHI1 and IFNGR1

		AHI1	IFNGR1
Description		Abelson helper integration site 1	interferon gamma receptor 1
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GO Annotations	Cellular Component	Centrosome Centriole Cytosol Cell-cell Junction Adherens Junction Cilium MKS Complex Ciliary Basal Body Non-motile Cilium	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Morphogenesis Of A Polarized Epithelium Heart Looping Positive Regulation Of Receptor Internalization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Central Nervous System Development Retina Layer Formation Vesicle-mediated Transport Positive Regulation Of Polarized Epithelial Cell Differentiation Hindbrain Development Cellular Protein Localization Cloaca Development Photoreceptor Cell Outer Segment Organization Pronephric Nephron Tubule Morphogenesis Pronephric Duct Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Behavior Cilium Assembly Specification Of Axis Polarity Kupffer's Vesicle Development Left/right Axis Specification Otic Vesicle Development	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation
Pathways		Anchoring of the basal body to the plasma membrane	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs			Interferon gamma-1b
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634 32296059) Basophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Hodgkin's lymphoma ( 29196614) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 24076602 21833088) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Nodular sclerosis Hodgkin lymphoma ( 29196614) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Selective IgA deficiency ( 27723758) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338 28714469) White blood cell count ( 32888494 27863252)	Behcet's disease ( 33393726) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		3 interacting genes: ARFGEF3 IFNGR1 KHDRBS1	17 interacting genes: AHI1 AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SLC9A6 SOCS1 STAT1 STIM1 TMEM100 TMEM237
Entrez ID		54806	3459
HPRD ID		10597	00127
Ensembl ID		ENSG00000135541	ENSG00000027697
Uniprot IDs		Q8N157 Q8NER0	A0A0S2Z3Y2 A0A2R8Y4U4 P15260
PDB IDs		4ESR	1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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