IFNGR1 and IFNGR2

Number of citations of the paper that reports this interaction (PubMedID 7673114)
35

Data Source:
HPRD (in vivo)

		IFNGR1	IFNGR2
Description		interferon gamma receptor 1	interferon gamma receptor 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding
	Biological Process	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs		Interferon gamma-1b	Interferon gamma-1b
Diseases
GWAS		Behcet's disease ( 33393726) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		17 interacting genes: AHI1 AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SLC9A6 SOCS1 STAT1 STIM1 TMEM100 TMEM237	46 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CCT8 CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 GRIK1 HCRTR1 HLCS IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24
Entrez ID		3459	3460
HPRD ID		00127	00956
Ensembl ID		ENSG00000027697	ENSG00000159128
Uniprot IDs		A0A0S2Z3Y2 A0A2R8Y4U4 P15260	A8K881 E7EUY1 P38484
PDB IDs		1FG9 1FYH 1JRH 6E3K 6E3L	5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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