IFNGR1 and SLC9A6

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IFNGR1	SLC9A6
Description		interferon gamma receptor 1	solute carrier family 9 member A6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Mitochondrion Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding	Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity
	Biological Process	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation	Ion Transport Axon Extension Neuron Projection Morphogenesis Regulation Of Intracellular PH Potassium Ion Transmembrane Transport Dendrite Extension Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS	Sodium/Proton exchangers Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)
Drugs		Interferon gamma-1b
Diseases
GWAS		Behcet's disease ( 33393726) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		17 interacting genes: AHI1 AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SLC9A6 SOCS1 STAT1 STIM1 TMEM100 TMEM237	2 interacting genes: CFTR IFNGR1
Entrez ID		3459	10479
HPRD ID		00127	02208
Ensembl ID		ENSG00000027697	ENSG00000198689
Uniprot IDs		A0A0S2Z3Y2 A0A2R8Y4U4 P15260	A0A1B0GV11 Q92581
PDB IDs		1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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