LEPROT and C1GALT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LEPROT	C1GALT1
Description		leptin receptor overlapping transcript	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Endosome Membrane Integral Component Of Membrane	Golgi Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Metal Ion Binding
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Localization To Cell Surface	Angiogenesis Kidney Development O-glycan Processing, Core 1 Cell Differentiation
Pathways			Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) O-linked glycosylation of mucins
Drugs
Diseases
GWAS		BMI at adiposity peak ( 31840077)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		11 interacting genes: AQP6 C1GALT1 GJA5 PLPPR1 SLC7A1 SMO SYNGR1 TMEM120A TMEM50A TMX2 YIPF1	32 interacting genes: ANKS6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GPR101 GPR151 GPR42 GPRC5D GPX8 GSDME LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC1A1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B TRAF6 XRN1
Entrez ID		54741	56913
HPRD ID		13987	16631
Ensembl ID		ENSG00000213625	ENSG00000106392
Uniprot IDs		A0A087X0N2 O15243	A0A024RA32 Q9NS00
PDB IDs
Enriched GO Terms of Interacting Partners?
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