C1GALT1 and PIGP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		C1GALT1	PIGP
Description		core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	phosphatidylinositol glycan anchor biosynthesis class P
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Metal Ion Binding	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	Angiogenesis Kidney Development O-glycan Processing, Core 1 Cell Differentiation	GPI Anchor Biosynthetic Process
Pathways		Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) O-linked glycosylation of mucins	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		32 interacting genes: ANKS6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GPR101 GPR151 GPR42 GPRC5D GPX8 GSDME LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC1A1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B TRAF6 XRN1	20 interacting genes: C1GALT1 C5 DHRSX DOP1B FIS1 IER3IP1 ITGAM LHFPL3 NINJ2 PLP1 PLP2 PTPN1 SCAMP5 SMAGP THSD7B TMEM107 TMEM19 TMEM229B UBIAD1 VPS26C
Entrez ID		56913	51227
HPRD ID		16631	05806
Ensembl ID		ENSG00000106392	ENSG00000185808
Uniprot IDs		A0A024RA32 Q9NS00	P57054
PDB IDs
Enriched GO Terms of Interacting Partners?
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