PDP1 and ACAT1

Number of citations of the paper that reports this interaction (PubMedID 24486017)
85

Data Source:
BioGRID (pull down)

		PDP1	ACAT1
Description		pyruvate dehydrogenase phosphatase catalytic subunit 1	acetyl-CoA acetyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Enzyme Binding Potassium Ion Binding Identical Protein Binding Coenzyme A Binding
	Biological Process	Protein Dephosphorylation Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity	Liver Development Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Brain Development Response To Hormone Response To Organic Cyclic Compound Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex	Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies
Drugs			Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS			Nonunion in individuals with fractures ( 30680360) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 OGT PDHA1 PLEKHF2 PRKCD SIRT3	5 interacting genes: AGXT CXCR4 PDP1 PEX7 PTPRF
Entrez ID		54704	38
HPRD ID		16185	01946
Ensembl ID		ENSG00000164951	ENSG00000075239
Uniprot IDs		A0A024R9C0 Q6P1N1 Q9P0J1	A0A140VJX1 A0A5F9ZHJ0 P24752
PDB IDs			2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
Enriched GO Terms of Interacting Partners?
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