PDP1 and SIRT3

Number of citations of the paper that reports this interaction (PubMedID 24486017)
85

Data Source:
BioGRID (pull down)

		PDP1	SIRT3
Description		pyruvate dehydrogenase phosphatase catalytic subunit 1	sirtuin 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Enzyme Binding NAD-dependent Protein Deacetylase Activity Sequence-specific DNA Binding NAD+ Binding
	Biological Process	Protein Dephosphorylation Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity	Protein ADP-ribosylation Protein Deacetylation Aging Aerobic Respiration Histone Deacetylation Positive Regulation Of Insulin Secretion Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex	Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation
Drugs			Adenosine-5-Diphosphoribose
Diseases
GWAS			Coronary artery disease ( 33020668) Glycated hemoglobin levels ( 34059833) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)
Interacting Genes		12 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 OGT PDHA1 PLEKHF2 PRKCD SIRT3	8 interacting genes: ALDH2 DNM1L H3C1 MDM2 PDP1 PEX5 PYCR1 XRCC6
Entrez ID		54704	23410
HPRD ID		16185	06836
Ensembl ID		ENSG00000164951	ENSG00000142082
Uniprot IDs		A0A024R9C0 Q6P1N1 Q9P0J1	Q9NTG7
PDB IDs			3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO
Enriched GO Terms of Interacting Partners?
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