POLE2 and ATOH1

		POLE2	ATOH1
Description		DNA polymerase epsilon 2, accessory subunit	atonal bHLH transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Chromatin Nucleus
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromatin DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Repair Error-prone Translesion Synthesis	Neuron Migration Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Notch Signaling Pathway Axon Guidance Central Nervous System Development Cerebral Cortex Development Neuron Differentiation Inner Ear Morphogenesis Auditory Receptor Cell Fate Specification Auditory Receptor Cell Fate Determination Negative Regulation Of Apoptotic Process Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS		Trigger finger ( 32740585)	Colorectal cancer or advanced adenoma ( 30510241) Metabolite levels ( 23823483)
Interacting Genes		25 interacting genes: AGFG1 ATOH1 BAIAP2L2 DRD3 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 NID2 PARK7 PKM POLE POLE4 PYGL REL SAP18 SAV1 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	3 interacting genes: HMGB1 HUWE1 POLE2
Entrez ID		5427	474
HPRD ID		16007	03270
Ensembl ID		ENSG00000100479	ENSG00000172238
Uniprot IDs		P56282	Q92858
PDB IDs		2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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