POLE2 and ZNF620

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		POLE2	ZNF620
Description		DNA polymerase epsilon 2, accessory subunit	zinc finger protein 620
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Repair Error-prone Translesion Synthesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Generic Transcription Pathway
Drugs		Cladribine
Diseases
GWAS		Trigger finger ( 32740585)	Neuroticism ( 29255261)
Interacting Genes		25 interacting genes: AGFG1 ATOH1 BAIAP2L2 DRD3 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 NID2 PARK7 PKM POLE POLE4 PYGL REL SAP18 SAV1 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	72 interacting genes: ABLIM3 ATG9A BFSP2 BOLA2 BOLA2B C1orf216 C22orf39 CABP5 CARD9 CCDC102B CCDC6 CCHCR1 CCNC CDCA7L CDKN2D CHAF1A CIB3 CINP CLIC3 CTNNA3 DGCR6L DTX2 EAF1 EEF2KMT EIF4A2 EPM2AIP1 EXOSC5 FHL2 GAS8 GLYCTK GRB2 GYS1 IGFN1 IL16 JRK KCTD9 LMO1 LMO3 MAGOHB MAP2K5 METTL21A MFAP1 MISP MLX MYOZ3 NDOR1 NME7 NOXA1 OAZ3 PIBF1 PIK3R3 PLOD3 POLE2 RIPPLY1 RUSC1 SAAL1 SART3 SLIT1 SNAPC3 TENT5B TPM2 TRAF4 TRIM10 TRIM50 TSEN15 TSR2 USP20 ZBTB16 ZFHX3 ZIC1 ZNF24 ZNF648
Entrez ID		5427	253639
HPRD ID		16007	15878
Ensembl ID		ENSG00000100479	ENSG00000177842
Uniprot IDs		P56282	Q6ZNG0
PDB IDs		2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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