POLE and GINS4

Number of citations of the paper that reports this interaction (PubMedID 21705323)
44

Data Source:
BioGRID (pull down)

		POLE	GINS4
Description		DNA polymerase epsilon, catalytic subunit	GINS complex subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	GINS Complex Nucleoplasm Cytoplasm CMG Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA-dependent DNA Replication
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Unwinding of DNA Unwinding of DNA
Drugs		Cladribine
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		19 interacting genes: ABHD16A EIF2B1 GINS4 MDM2 MMP17 NOS1 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 RAN SCARB1 STK19 TOPBP1 ULK1 VSIG4 XRCC5	18 interacting genes: - BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 IDO2 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1
Entrez ID		5426	84296
HPRD ID		07177	11583
Ensembl ID		ENSG00000177084	ENSG00000147536
Uniprot IDs		Q07864	Q9BRT9
PDB IDs		5VBN	2E9X 2EHO 2Q9Q 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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