GINS4 and MCM2

Number of citations of the paper that reports this interaction (PubMedID 22374673)
12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		GINS4	MCM2
Description		GINS complex subunit 4	minichromosome maintenance complex component 2
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GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm CMG Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm MCM Complex CMG Complex
	Molecular Function	Protein Binding	DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA-dependent DNA Replication	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation Negative Regulation Of DNA Helicase Activity
Pathways		Unwinding of DNA Unwinding of DNA	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: - BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 IDO2 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1	58 interacting genes: AKAP8 APP ASF1A ATM ATR CCNB2 CCNC CD86 CDC45 CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CDT1 CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GINS4 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP
Entrez ID		84296	4171
HPRD ID		11583	00303
Ensembl ID		ENSG00000147536	ENSG00000073111
Uniprot IDs		Q9BRT9	P49736
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY	4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7
Enriched GO Terms of Interacting Partners?
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