POLE and RAD17

Number of citations of the paper that reports this interaction (PubMedID 14500819)
17

Data Source:
HPRD (in vivo, in vitro)

		POLE	RAD17
Description		DNA polymerase epsilon, catalytic subunit	RAD17 checkpoint clamp loader component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding	Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs		Cladribine
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		19 interacting genes: ABHD16A EIF2B1 GINS4 MDM2 MMP17 NOS1 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 RAN SCARB1 STK19 TOPBP1 ULK1 VSIG4 XRCC5	16 interacting genes: ATM ATR F2RL1 HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20
Entrez ID		5426	5884
HPRD ID		07177	09124
Ensembl ID		ENSG00000177084	ENSG00000152942
Uniprot IDs		Q07864	O75943
PDB IDs		5VBN
Enriched GO Terms of Interacting Partners?
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