CYCS and COX4I2

Number of citations of the paper that reports this interaction (PubMedID 10683230)
9

Data Source:
HPRD (in vitro)

		CYCS	COX4I2
Description		cytochrome c, somatic	cytochrome c oxidase subunit 4I2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome	Mitochondrial Respiratory Chain Complex IV Integral Component Of Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	Cytochrome-c Oxidase Activity
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration	Generation Of Precursor Metabolites And Energy Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Cellular Response To Hypoxia Proton Transmembrane Transport
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1
Drugs		Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)	Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070)
Interacting Genes		22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	2 interacting genes: APP CYCS
Entrez ID		54205	84701
HPRD ID		00479	12143
Ensembl ID		ENSG00000172115	ENSG00000131055
Uniprot IDs		G4XXL9 P99999	H6SG14 Q96KJ9
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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