CYCS and FDX1

Number of citations of the paper that reports this interaction (PubMedID 6270113)
3

Data Source:
HPRD (in vivo)

		CYCS	FDX1
Description		cytochrome c, somatic	ferredoxin 1
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration	Steroid Biosynthetic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP Cellular Response To Forskolin
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR
Drugs		Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol	Mitotane
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)	Cognitive function ( 24684796) Coronary artery disease ( 32469254) Serum metabolite levels ( 33031748)
Interacting Genes		22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	12 interacting genes: BIRC2 BIRC3 CNTN5 CORO2A CYCS CYP11A1 CYP11B2 FDXR LILRB2 PBRM1 PRKAB2 RDH5
Entrez ID		54205	2230
HPRD ID		00479	00059
Ensembl ID		ENSG00000172115	ENSG00000137714
Uniprot IDs		G4XXL9 P99999	P10109
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ	3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?
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