CYCS and CUL9

Number of citations of the paper that reports this interaction (PubMedID 25028717)
22

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CYCS	CUL9
Description		cytochrome c, somatic	cullin 9
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome	Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Protein Ubiquitination
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1	Neddylation
Drugs		Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)	Adult hearing difficulty ( 31564434) General risk tolerance (MTAG) ( 30643258) Obesity-related traits ( 23251661) Tea consumption ( 31046077) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	8 interacting genes: CYCS MTDH PLXNB3 TP53 UBE2E2 UBE2G1 UBE2G2 UBE2L3
Entrez ID		54205	23113
HPRD ID		00479	06317
Ensembl ID		ENSG00000172115	ENSG00000112659
Uniprot IDs		G4XXL9 P99999	Q8IWT3
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ	2JUF
Enriched GO Terms of Interacting Partners?
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