BRWD1 and CUL4B

Number of citations of the paper that reports this interaction (PubMedID 31973889)
8

Data Source:
BioGRID (affinity chromatography technology, pull down)

		BRWD1	CUL4B
Description		bromodomain and WD repeat domain containing 1	cullin 4B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Nucleoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Molecular_function	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape	G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Histone H2A Monoubiquitination Ribosome Biogenesis UV-damage Excision Repair
Pathways		Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Cognitive function ( 25644384) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) General cognitive ability ( 29844566) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 25231870) Platelet distribution width ( 32888494) Smoking initiation ( 33082346) Temperament (bipolar disorder) ( 22365631) Total cholesterol levels ( 30275531)
Interacting Genes		15 interacting genes: ADD2 APP APPL1 CALM1 CUL4B EIF4E FNDC3B HDAC7 NRF1 NUTF2 SMARCA4 SMARCD1 STAT3 TRIM55 TRIM63	55 interacting genes: AHR AMBRA1 APP AR BRWD1 BRWD3 CAND1 COMMD1 COP1 COPS2 COPS5 CRBN CUL4A DCAF10 DCAF11 DCAF12 DCAF15 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCUN1D1 DCUN1D4 DDA1 DDB1 DDB2 DET1 DNMT3B DTL ERCC8 ESR1 GLMN HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PHIP PLS3 PRDX3 PTEN PWP1 RBX1 RNF7 SALL2 SIN3A SRC ST7 TBL3 TRPC4AP UBC UBE2D3 WDTC1 ZMAT4
Entrez ID		54014	8450
HPRD ID		11683	02251
Ensembl ID		ENSG00000185658	ENSG00000158290
Uniprot IDs		Q9NSI6	K4DI93 Q13620
PDB IDs		3Q2E	2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?
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