CUL4B and DTL

Number of citations of the paper that reports this interaction (PubMedID 31973889)
8

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CUL4B	DTL
Description		cullin 4B	denticleless E3 ubiquitin protein ligase homolog
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Histone H2A Monoubiquitination Ribosome Biogenesis UV-damage Excision Repair	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Response To UV Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Translesion Synthesis Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Cell Cycle
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Recognition of DNA damage by PCNA-containing replication complex Neddylation
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)
Interacting Genes		55 interacting genes: AHR AMBRA1 APP AR BRWD1 BRWD3 CAND1 COMMD1 COP1 COPS2 COPS5 CRBN CUL4A DCAF10 DCAF11 DCAF12 DCAF15 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCUN1D1 DCUN1D4 DDA1 DDB1 DDB2 DET1 DNMT3B DTL ERCC8 ESR1 GLMN HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PHIP PLS3 PRDX3 PTEN PWP1 RBX1 RNF7 SALL2 SIN3A SRC ST7 TBL3 TRPC4AP UBC UBE2D3 WDTC1 ZMAT4	18 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 CUL4B DDB1 KAT2A KMT5A PCNA POLD4 RBX1 TDG TOB1 TP53 UBE2D1 UBE2N
Entrez ID		8450	51514
HPRD ID		02251	17952
Ensembl ID		ENSG00000158290	ENSG00000143476
Uniprot IDs		K4DI93 Q13620	B4E0E6 Q9NZJ0
PDB IDs		2DO7 4A0C 4A0L 4A64	6QC0
Enriched GO Terms of Interacting Partners?
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