PLEC and PLEKHA5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		PLEC	PLEKHA5
Description		plectin	pleckstrin homology domain containing A5
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Z Disc Hemidesmosome Axon Dendrite Sarcolemma Costamere Myelin Sheath Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Dystroglycan Binding RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Protein Self-association Cadherin Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Cell Morphogenesis Leukocyte Migration Involved In Immune Response Keratinocyte Development Negative Regulation Of Protein Kinase Activity Nucleus Organization Gene Expression Fibroblast Migration T Cell Chemotaxis Skeletal Myofibril Assembly Transmission Of Nerve Impulse Respiratory Electron Transport Chain Actin Cytoskeleton Reorganization Hemidesmosome Assembly Cellular Response To Extracellular Stimulus Response To Food Peripheral Nervous System Myelin Maintenance Adherens Junction Organization Cellular Protein Localization Multicellular Organism Growth Wound Healing Regulation Of Vascular Permeability Protein-containing Complex Subunit Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Sarcomere Organization Myoblast Differentiation Skeletal Muscle Fiber Development Cardiac Muscle Cell Development Establishment Of Skin Barrier Mitochondrion Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Hydrostatic Pressure Cellular Response To Fluid Shear Stress Tight Junction Organization Actomyosin Contractile Ring Assembly Actin Filament Organization Regulation Of ATP Citrate Synthase Activity	Biological_process Reproductive System Development
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 28107422 26561523) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip index ( 34021172) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricular ejection fraction (MTAG) ( 33495596) Left ventricular global radial strain (MTAG) ( 33495596) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Periodontitis (stage III/IV grade C) ( 33745150) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes		24 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SNAPIN SPTA1 SPTAN1 SUMO2 UBC VIM	36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		5339	54477
HPRD ID		03180	09684
Ensembl ID		ENSG00000178209	ENSG00000052126
Uniprot IDs		Q15149	A0A024RAY7 Q9HAU0
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I	2DKP
Enriched GO Terms of Interacting Partners?
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