PLAT and EIF4EBP1

		PLAT	EIF4EBP1
Description		plasminogen activator, tissue type	eukaryotic translation initiation factor 4E binding protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding
	Biological Process	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Menopause (age at onset) ( 29773799)
Interacting Genes		37 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC VDAC1	41 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 FGFR1 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD NRG1 PICK1 PLAT POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655
Entrez ID		5327	1978
HPRD ID		01419	03746
Ensembl ID		ENSG00000104368	ENSG00000187840
Uniprot IDs		B4DN26 P00750	Q13541
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ	1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX
Enriched GO Terms of Interacting Partners?
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