PLAT and SERPINI1

Number of citations of the paper that reports this interaction (PubMedID 12228252)
20

Data Source:
HPRD (in vivo, in vitro)

		PLAT	SERPINI1
Description		plasminogen activator, tissue type	serpin family I member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Space Secretory Granule Lumen Neuronal Cell Body Perikaryon Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Central Nervous System Development Peripheral Nervous System Development Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion
Pathways		Signaling by PDGF Dissolution of Fibrin Clot
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Eye color (saturation) ( 30664655) Fast beta electroencephalogram ( 28070124) Heart rate ( 23534349) Height ( 18391951) Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655)
Interacting Genes		37 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC VDAC1	3 interacting genes: PLAT PLG TSC2
Entrez ID		5327	5274
HPRD ID		01419	03901
Ensembl ID		ENSG00000104368	ENSG00000163536
Uniprot IDs		B4DN26 P00750	A0A0S2Z455 Q99574
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ	3F02 3F5N 3FGQ
Enriched GO Terms of Interacting Partners?
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