EIF4EBP1 and NRG1

		EIF4EBP1	NRG1
Description		eukaryotic translation initiation factor 4E binding protein 1	neuregulin 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Integral Component Of Plasma Membrane Membrane Axon Neuromuscular Junction Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity ErbB-2 Class Receptor Binding Integrin Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation	MAPK Cascade Cell Morphogenesis Cardiac Conduction System Development Ventricular Trabecula Myocardium Morphogenesis Cell Communication Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Synapse Assembly Locomotory Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Neural Crest Cell Development Glial Cell Fate Commitment Chemorepulsion Involved In Interneuron Migration From The Subpallium To The Cortex Myelination In Peripheral Nervous System Cell Differentiation Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB3 Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Neurotransmitter Receptor Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Animal Organ Development Neuron Fate Commitment Oligodendrocyte Differentiation Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Neuron Migration
Pathways		mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Bone mineral density (hip) ( 30172743) Cardiac Troponin-T levels ( 23247143) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Cleft lip with or without cleft palate ( 28054174) Cognitive function ( 25644384) Coronary artery calcification ( 23870195) Dialysis-related mortality ( 21546767) Differentiated thyroid cancer ( 28703219) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 30604766) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip geometry ( 17903296) Hirschsprung disease ( 19196962 25310821 27702942) Hypothyroidism ( 27182965) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Major depressive disorder ( 29317602) Malaria ( 31844061) Metabolite levels (X-11787) ( 23934736) Morning person ( 30696823) Non-small cell lung cancer ( 31326317) Obstructive sleep apnea ( 25325441) Orofacial clefts ( 28054174) Papillary thyroid cancer ( 28703219) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Refractive astigmatism ( 25367360) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Rheumatic heart disease ( 34106200) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		41 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 FGFR1 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD NRG1 PICK1 PLAT POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655	23 interacting genes: ADAM19 ADGRA2 ASGR2 CD72 CEBPD DKK4 EGF EGFR EIF4EBP1 ERBB2 ERBB3 ERBB4 FGFR1 IKZF4 ISG20 JAGN1 KCNK4 LAPTM4B LIMK1 LIPF MS4A4A PLP1 TMEM54
Entrez ID		1978	3084
HPRD ID		03746	00802
Ensembl ID		ENSG00000187840	ENSG00000157168
Uniprot IDs		Q13541	A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 F6RJN6 Q02297 Q6PK61 Q7RTW3 Q7RTW5
PDB IDs		1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX	1HAE 1HAF 1HRE 1HRF 3U7U
Enriched GO Terms of Interacting Partners?
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