PGK1 and UBE3A

Number of citations of the paper that reports this interaction (PubMedID 31329371)
1

Data Source:
BioGRID (pull down)

		PGK1	UBE3A
Description		phosphoglycerate kinase 1	ubiquitin protein ligase E3A
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol Membrane Membrane Raft Extracellular Exosome	Proteasome Complex Nucleus Cytosol
	Molecular Function	Phosphoglycerate Kinase Activity Protein Binding ATP Binding ADP Binding Protein-disulfide Reductase (NAD(P)) Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Gluconeogenesis Glycolytic Process Phosphorylation Negative Regulation Of Angiogenesis Epithelial Cell Differentiation Plasminogen Activation Cellular Response To Hypoxia	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Locomotory Exploration Behavior Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Motor Learning Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate 3-phospho-D-glyceric acid Copper Artenimol
Diseases
GWAS		Mean platelet volume ( 32888494)	Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		18 interacting genes: AR BECN1 CDC7 CSNK2A1 DISC1 GAPDH HIF1A HSPH1 LINC01554 NAA10 OGT PCNA RHOU SUMO2 SUMO4 TUBA1A UBE3A YWHAQ	150 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CTNNB1 DAZAP2 DLG1 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM7 MDM1 MDM2 MEOX2 MSTO1 MYCBP NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446
Entrez ID		5230	7337
HPRD ID		02412	03375
Ensembl ID		ENSG00000102144	ENSG00000114062
Uniprot IDs		P00558 V9HWF4	Q05086 Q9H2G0
PDB IDs		2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33 5M1R 5M3U 5M6Z 5MXM 5NP8 5O7D	1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19
Enriched GO Terms of Interacting Partners?
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