UBE3A and ALDH1A2

Number of citations of the paper that reports this interaction (PubMedID 32545848)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology, enzymatic study)

		UBE3A	ALDH1A2
Description		ubiquitin protein ligase E3A	aldehyde dehydrogenase 1 family member A2
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Retinal Dehydrogenase Activity 3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Retinal Binding
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Locomotory Exploration Behavior Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Motor Learning Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Blood Vessel Development Kidney Development Liver Development Regulation Of Endothelial Cell Proliferation Retinoic Acid Biosynthetic Process Heart Morphogenesis Vitamin A Metabolic Process Midgut Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Determination Of Bilateral Symmetry Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Neural Crest Cell Development Morphogenesis Of Embryonic Epithelium Neural Tube Development Pituitary Gland Development Neuron Differentiation Lung Development Hindbrain Development Pancreas Development Embryonic Camera-type Eye Development Response To Estradiol Response To Vitamin A Response To Cytokine Embryonic Forelimb Morphogenesis Ureter Maturation Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process 9-cis-retinoic Acid Biosynthetic Process Positive Regulation Of Apoptotic Process Embryonic Digestive Tract Development Cardiac Muscle Tissue Development Protein Homotetramerization Face Development Cellular Response To Retinoic Acid Retinoic Acid Receptor Signaling Pathway Involved In Somitogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RA biosynthesis pathway
Drugs			NADH Vitamin A Tretinoin
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Apolipoprotein A1 levels ( 33730874) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Cholesterol ( 31902109) Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494) HDL cholesterol ( 28270201 30275531) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 19609347) Ischemic stroke ( 26089329) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low HDL-cholesterol levels ( 31910446) Lymphocyte counts ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Osteoarthritis (hand, severe) ( 24728293) Red blood cell count ( 32888494) Serum metabolite levels ( 33031748) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Total cholesterol levels ( 30275531) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32154731) Uncontrolled blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388)
Interacting Genes		150 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CTNNB1 DAZAP2 DLG1 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM7 MDM1 MDM2 MEOX2 MSTO1 MYCBP NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446	3 interacting genes: HTRA2 OGT UBE3A
Entrez ID		7337	8854
HPRD ID		03375	04733
Ensembl ID		ENSG00000114062	ENSG00000128918
Uniprot IDs		Q05086 Q9H2G0	O94788
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19	4X2Q 6ALJ 6B5G 6B5H 6B5I
Enriched GO Terms of Interacting Partners?
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