PDGFRA and SPOCK1

		PDGFRA	SPOCK1
Description		platelet derived growth factor receptor alpha	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Membrane Cell Junction Intrinsic Component Of Plasma Membrane Protein-containing Complex Receptor Complex	Extracellular Space Cytoplasm Postsynaptic Density Sarcoplasm Neuromuscular Junction Node Of Ranvier
	Molecular Function	Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Metalloendopeptidase Inhibitor Activity
	Biological Process	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Positive Regulation Of Kinase Activity Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis White Fat Cell Differentiation Regulation Of Chemotaxis Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation	Regulation Of Cell Growth Neuron Migration Cell Adhesion Nervous System Development Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Negative Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Neurogenesis
Pathways		PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs		Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases
GWAS		Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 22144915 29422769) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 29403010 20139978) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 29403010 28453575 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Body mass index ( 28552196) Bronchopulmonary dysplasia ( 23897914) HIV-1 susceptibility ( 25786224) Mathematical ability ( 28155865) Metabolite levels ( 23823483) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to quetiapine in schizophrenia ( 29503163) Weight ( 28552196)
Interacting Genes		68 interacting genes: AKT1 ALB ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD244 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR EPHA2 ERBB2 ERBB3 FBXO25 FGFR4 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 RAPGEF1 SHB SHF SLC9A3R1 SMURF1 SNX2 SNX4 SNX6 SPOCK1 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2	6 interacting genes: BCL2L13 CREB3L1 MMP14 MMP2 MMP3 PDGFRA
Entrez ID		5156	6695
HPRD ID		01429	11887
Ensembl ID		ENSG00000134853	ENSG00000152377
Uniprot IDs		P16234	Q08629
PDB IDs		1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL
Enriched GO Terms of Interacting Partners?
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