SPOCK1 and MMP2

Number of citations of the paper that reports this interaction (PubMedID 12810672)
22

Data Source:
HPRD (in vitro)

		SPOCK1	MMP2
Description		SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	matrix metallopeptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Postsynaptic Density Sarcoplasm Neuromuscular Junction Node Of Ranvier	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Metalloendopeptidase Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Regulation Of Cell Growth Neuron Migration Cell Adhesion Nervous System Development Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Negative Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Neurogenesis	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways			Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs			Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin
Diseases
GWAS		Body mass index ( 28552196) Bronchopulmonary dysplasia ( 23897914) HIV-1 susceptibility ( 25786224) Mathematical ability ( 28155865) Metabolite levels ( 23823483) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to quetiapine in schizophrenia ( 29503163) Weight ( 28552196)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: BCL2L13 CREB3L1 MMP14 MMP2 MMP3 PDGFRA	39 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		6695	4313
HPRD ID		11887	00386
Ensembl ID		ENSG00000152377	ENSG00000087245
Uniprot IDs		Q08629	A0A024R6R4 P08253
PDB IDs			1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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