EVL and ZYX

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid, proximity labelling technology)

		EVL	ZYX
Description		Enah/Vasp-like	zyxin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium	Stress Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Cell-matrix Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Regulation Of Inflammatory Response Cellular Response To Interferon-gamma
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs			Artenimol
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		45 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP ATG2B BDKRB1 BEGAIN C14orf132 CKB CRKL DNMBP ENAH F11R FXR1 FXR2 FYB1 FYN GSKIP HCK HTT KRT17 KRT34 LRP1B LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	35 interacting genes: ACTN1 ATXN1 BSPRY CASS4 ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B
Entrez ID		51466	7791
HPRD ID		10942	03592
Ensembl ID		ENSG00000196405	ENSG00000159840
Uniprot IDs		A0A024R6K5 Q9UI08	Q15942 Q96AF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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