ZYX and LAP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZYX	LAP3
Description		zyxin	leucine aminopeptidase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle	Nucleus Nucleoplasm Trans-Golgi Network Cytosol Focal Adhesion Midbody Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding	Aminopeptidase Activity Carboxypeptidase Activity Protein Binding Metalloexopeptidase Activity Manganese Ion Binding Metalloaminopeptidase Activity
	Biological Process	Cell-matrix Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Regulation Of Inflammatory Response Cellular Response To Interferon-gamma	Proteolysis
Pathways
Drugs		Artenimol	Leucine Phosphonic Acid (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid Zofenoprilat
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		35 interacting genes: ACTN1 ATXN1 BSPRY CASS4 ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B	14 interacting genes: APP BANP CBX3 CBX5 FXR1 LIG4 MAPRE3 OGT PIH1D2 PIK3R3 TAB1 USF1 ZNF76 ZYX
Entrez ID		7791	51056
HPRD ID		03592	07516
Ensembl ID		ENSG00000159840	ENSG00000002549
Uniprot IDs		Q15942 Q96AF9	P28838
PDB IDs
Enriched GO Terms of Interacting Partners?
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