PDCD1 and CD274

Number of citations of the paper that reports this interaction (PubMedID 12719480)
90

Data Source:
HPRD (in vivo)

		PDCD1	CD274
Description		programmed cell death 1	CD274 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Apoptotic Process Humoral Immune Response Multicellular Organism Development Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of T Cell Apoptotic Process	Adaptive Immune Response Positive Regulation Of Tolerance Induction To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		PD-1 signaling Potential therapeutics for SARS	PD-1 signaling STAT3 nuclear events downstream of ALK signaling
Drugs		CT-011 Nivolumab Pembrolizumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680	Atezolizumab Durvalumab Avelumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178
Diseases
GWAS		Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: CD274 COPS8 MCL1 OR6B3 PDCD1LG2	6 interacting genes: CD80 COPS5 CREB1 OTUB1 PDCD1 VLDLR
Entrez ID		5133	29126
HPRD ID		02590	05655
Ensembl ID		ENSG00000188389	ENSG00000120217
Uniprot IDs		A0A0M3M0G7 Q15116	Q0GN75 Q9NZQ7
PDB IDs		2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CU5	3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6L8R 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG 6VQN 6YCR
Enriched GO Terms of Interacting Partners?
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